Pseudomonas infections are very hard to treat in immunocompromised patients, in the post operational and other hospitalization related conditions and are responsible for high number of deaths. Thus Pseudomonas can be very notorious opportunistic pathogen. The major problem associated with chronic P. aeruginosa infections is the development of antibiotic resistance due to long continuous treatment durations in which the resistant mutants start to accumulate. Recent understandings regarding the development of antibiotic resistance have added a new dimension of hypermutator strains which have comparatively high rates of mutations then wild type strains. In Ayurveda, many plants and plant extracts have been widely used for treatment of diseases which may be due to bacterial, fungal or viral pathogen or due to imbalance in the body’s various systems. Modulation of immune response to alleviate disease has been one of the ways practiced in ayurveda including others such as re-establishing the imbalance in the body, lifestyle changes, and diet. The plants extracts used are seeds of Moringa oleifera, Nigella sativa, Vernonia anthelmintica, fruit of Terminalia chebula and root bark of Terminalia bellerica. These plant extracts have been shown to be effective as an antibacterial agent specifically against P. aeruginosa. The plant extracts used in this study are easily available and is being used in normal day-to-day life for various purpose and also have been proven to be effective medicine in Ayurveda.
Inhaltsverzeichnis (Table of Contents)
- Chapter 1: Introduction & Review of Literature
- Characteristics
- Pseudomonas aeruginosa as a Human pathogen
- Virulence factors of P. aeruginosa
- Quorum sensing: A Global Regulation System of P. aeruginosa Extracellular Virulence Factors
- Host Defenses
- Epidemiology and Control of P. aeruginosa Infections
- Toxinogenesis
- Current Therapeutic Approaches
- Novel Therapeutic Approaches
- Probable Drawbacks
- Role of Plant Extracts
- Chapter 2: Materials & Methods
- Phase I In vivo study
- Phase II In vitro study
- Chapter 3: RESULTS
- Chapter 4: DISCUSSION
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
This work aims to provide a comprehensive review of Pseudomonas aeruginosa, focusing on its characteristics, pathogenicity, and the challenges in treating infections caused by this bacterium. The research likely investigates potential novel therapeutic approaches, possibly involving plant extracts.
- Characteristics and ecology of P. aeruginosa
- P. aeruginosa as an opportunistic human pathogen and its virulence factors
- Challenges in treating P. aeruginosa infections, including antibiotic resistance
- Exploration of novel therapeutic strategies
- The role of plant extracts in combating P. aeruginosa infections
Zusammenfassung der Kapitel (Chapter Summaries)
Chapter 1: Introduction & Review of Literature: This chapter introduces Pseudomonas aeruginosa, a Gram-negative bacterium commonly found in various environments, including soil, water, and plants. It discusses P. aeruginosa's characteristics, emphasizing its remarkable adaptability and ability to thrive in diverse conditions, including harsh environments such as diesel fuel. The chapter details its classification within the Gamma Proteobacteria, its metabolic capabilities, and its emergence as a significant opportunistic human pathogen, particularly in nosocomial settings. It highlights the bacterium's virulence factors, mechanisms of infection, and the complexities of treating infections due to its propensity to develop antibiotic resistance. The review delves into the current and novel therapeutic approaches, including the potential of plant extracts, while acknowledging the drawbacks of existing treatments. The section on antibiotic resistance extensively covers the development of hypermutator strains, emphasizing the significant challenge posed by these highly resistant variants to current antimicrobial therapies. This chapter sets the stage for the rest of the work by providing a comprehensive background on P. aeruginosa and the challenges associated with its treatment.
Chapter 2: Materials & Methods: This chapter outlines the methodologies employed in the research. It details the experimental design, including both in vivo (Phase I) and in vitro (Phase II) studies. While specifics are not provided here, the chapter lays the foundation for understanding the approach taken to investigate the research questions posed in the introduction. The description would likely include details on participant selection (for in vivo studies), sample preparation and handling, specific laboratory techniques, and statistical analyses performed to evaluate the data obtained from the experiments.
Schlüsselwörter (Keywords)
Pseudomonas aeruginosa, opportunistic pathogen, antibiotic resistance, virulence factors, quorum sensing, nosocomial infections, plant extracts, novel therapeutic approaches, hypermutator strains, biofilm.
Frequently Asked Questions: Pseudomonas aeruginosa Research Preview
What is the focus of this research preview?
This preview summarizes a research project focusing on Pseudomonas aeruginosa, a significant opportunistic human pathogen. It covers the bacterium's characteristics, pathogenicity, and the challenges associated with treating infections caused by it, with a particular emphasis on exploring novel therapeutic approaches, potentially utilizing plant extracts.
What topics are covered in the "Introduction & Review of Literature"?
Chapter 1 provides a comprehensive overview of Pseudomonas aeruginosa, including its characteristics, classification, metabolic capabilities, virulence factors, mechanisms of infection, and the development of antibiotic resistance (including hypermutator strains). It also reviews current and novel therapeutic approaches, highlighting the potential of plant extracts and the drawbacks of existing treatments.
What methodologies are described in the "Materials & Methods" section?
Chapter 2 details the research methodology, outlining both in vivo (Phase I) and in vitro (Phase II) studies. While specific details aren't provided in this preview, it mentions the experimental design, sample preparation, laboratory techniques, and statistical analyses used.
What are the key themes of the research?
Key themes include the characteristics and ecology of P. aeruginosa; its role as an opportunistic human pathogen and its virulence factors; challenges in treating infections, particularly antibiotic resistance; the exploration of novel therapeutic strategies; and the potential role of plant extracts in combating P. aeruginosa infections.
What are the main objectives of the research?
The primary objective is to provide a thorough review of Pseudomonas aeruginosa, addressing its characteristics, pathogenicity, and the difficulties in treating its infections. A key aim is to investigate potential novel therapeutic approaches.
What are the key words associated with this research?
Keywords include Pseudomonas aeruginosa, opportunistic pathogen, antibiotic resistance, virulence factors, quorum sensing, nosocomial infections, plant extracts, novel therapeutic approaches, hypermutator strains, and biofilm.
What is the structure of the research preview?
The preview includes a table of contents, objectives and key themes, chapter summaries, and keywords. It provides a concise overview of the research project without delving into the detailed results or discussion.
- Arbeit zitieren
- Sriram Seshadri (Autor:in), 2011, Plant Extracts against Pseudomonas Aeroginosa - in Vitro & in Vovo Studies, München, GRIN Verlag, https://www.hausarbeiten.de/document/188467
