The monograph summarizes for the first time the data of the literature and own preclinical and clinical studies of iron (IV) clatrochelate. Data on its physicochemical properties, acute and chronic toxicity, features of accumulation of iron in new rare valences in the form of clatrochelate are described. For the first time its antianemic activity is characterized.
The scientific publication is intended for a wide range of scientists, teachers, graduate students, students of higher education institutions, veterinary specialists.
An animal health is now regarded as one of the factors of the veterinary well-being in every country, so the issue of treating animals with pathological conditions and their prevention is given considerable attention by both scientists and veterinary practitioners. Uncontrolled usage of medicines cause an increase of toxic effects in human and animals organisms. In accordance with the guidelines of the preclinical study of drugs, every new drug must be evaluated for the following indicators: the toxicity of the bioassay to infusoria; the toxicity in laboratory animals after a single administration (acute toxicity); the cumulative properties; the toxicity in laboratory animals after long-term administration (chronic toxicity).
The following study works with animal obduction and shows the methodology in pictures.
Inhaltsverzeichnis (Table of Contents)
- ACUTE TOXICITY OF THE IRON(IV) CLATHROCHELATE COMPLEX
- Setting the acute toxicity of the Iron(IV) clathrochelate for intragastric administration to the quails
- CHRONIC TOXICITY OF THE IRON(IV) CLATHROCHELATE COMPLEXES TO RODENTS
- Setting the toxicity of the Iron (IV) clathrochelate on the white mice
- Chronic toxicity of the Iron(IV) clathrochelate complexes to white rats
- Cumulative properties of Iron(IV) clathrochelate in rats
- CHRONIC TOXICITY OF THE IRON(IV) CLATHROCHELATE COMPLEXES TO THE QUAILS
- Change of the body weight of quails during prolonged use of the Iron(IV) clathrochelate complex
- Change of relative mass of the organs of quails after prolonged use of the Iron(IV) clathrochelate complex
- Change of the content of hemoglobin and the morphological parameters of the blood of the quails during prolonged use of the Iron(IV) clathrochelate complex
- Change of the biochemical parameters of the serum of the blood of the quails during prolonged use of the Iron(IV) clathrochelate complex
- ANTIANEMIC ACTION OF THE IRON(IV) CLATHROCHELATE COMPLEXES
- Change of the body weight of piglets under the influence of Iron (IV)
- Change of the hemoglobin content and morphological indicators of blood of piglets under the influence of Iron(IV)
- Leukogram of blood of piglets under the influence of Iron (IV)
- Biochemical indicators of blood serum of piglets under the influence of Iron(IV)
- Change of the mass fraction of Iron in blood, liver and spleen of piglets under the influence of Iron (IV)
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
This monograph aims to present the physicochemical properties and analyze the effect on the body of laboratory animals of hexahydrazide Iron(IV) hexahydrazide with single and repeated use. It examines the acute and chronic toxicity of this compound and presents the first clinical research findings.
- Acute and chronic toxicity of Iron(IV) clathrochelate complexes in various animal models.
- Pharmacological action of Iron(IV) compounds in laboratory animals.
- Effects of Iron(IV) clathrochelate complexes on body weight, organ mass, blood parameters, and biochemical indicators.
- Antianemic action of Iron(IV) clathrochelate complexes in piglets.
- Comparison of Iron(IV) clathrochelate complexes with existing iron preparations and their potential for veterinary medicine.
Zusammenfassung der Kapitel (Chapter Summaries)
- Chapter 1 focuses on the acute toxicity of Iron(IV) clathrochelate complexes, specifically examining the lethal dose for quails following intragastric administration.
- Chapter 2 delves into the chronic toxicity of Iron(IV) clathrochelate complexes in rodents, including white mice and rats. This chapter examines the effects on the animals' health and the cumulative properties of the compound.
- Chapter 3 investigates the chronic toxicity of Iron(IV) clathrochelate complexes in quails, analyzing the impact on body weight, organ mass, blood parameters, and biochemical indicators.
- Chapter 4 explores the antianemic action of Iron(IV) clathrochelate complexes in piglets, examining changes in body weight, hemoglobin content, blood morphology, and other relevant indicators.
Schlüsselwörter (Keywords)
The primary focus of this work is on the pharmaco-toxicological characteristics of Iron(IV) clathrochelate complexes. Key terms and concepts include acute and chronic toxicity, preclinical studies, veterinary medicine, iron deficiency anemia, iron supplementation, high-valent iron compounds, clathrochelate ligands, and laboratory animal models.
- Quote paper
- Iryna Derkach (Author), V. B. Dukhnitskyі (Author), S. S. Derkach (Author), I. O. Fritsky (Author), M. O. Plutenko (Author), V. M. Lozovyi (Author), 2020, Pharmaco-toxicological characteristic of Iron(IV) clathrochelate complex. An analysis, Munich, GRIN Verlag, https://www.hausarbeiten.de/document/989450
