The present study was designed to synthesis potassium dicitro bismuthate (III) complex. The complex was characterized by infrared spectra, conductivity and elemental analysis of Bi. The effect of gastro protection was investigated for the prepared complex against HCl- ethanol induced ulcer in rats. The complex was administered to rats at 50 and 100 mg\kg doses orally before one hour of receiving 0.2ml of HCl- ethanol mixture to induce gastric ulcer. Sucralfate (100mg\ kg, orally) was used as standard drug. The severity of gastro mucosal damage induced by HCl-ethanol was analyzed in term of ulcer index value. Administration of potassium dicitro bismuthate (III) one hour before HCl-ethanol had significantly decreased ulcer index value when compared to saline treated group. Sucralfate (100mg\kg, orally) also produced a significant decrease in ulcer index when compared with the saline treated group. There was no significant difference between potassium dicitro bismuthate (III) and Sucralfate in degree of protection against ulcer. Thus it can be concluded that potassium dicitro bismuthate (III) has antiulcer activity in rats.
Inhaltsverzeichnis (Table of Contents)
- ABSTRACT
- Keywords
- INTRODUCTION
- MATERIALS AND METHODS
- All the materials (BDH) were used without any further purification.
- Preparation of Bismuth complex
- Physical measurements
- Pharmaceutical study
- Histological evaluation
- Histopathological studies
- Statistical analysis
- RESULTS AND DISCUSSION
- A- Structure assignment
- Fourier transform-infrared spectroscopy (FTIR)
- Citric acid
- potassiumdicitro bismuthate (III) complex
- B- Antiulcer activity of the complex
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
The study aims to synthesize and characterize the potassium dicitro bismuthate (III) complex and evaluate its antiulcer activity against HCl-ethanol induced gastric ulcer in rats. The research utilizes methods including FTIR spectroscopy, conductivity, and elemental analysis for complex characterization.
- Synthesis and characterization of potassium dicitro bismuthate (III) complex
- Evaluation of antiulcer activity in rats
- Comparison of the complex's efficacy to Sucralfate, a standard antiulcer drug
- Histological analysis of gastric mucosa
- Investigation of the relationship between the complex's structure and its antiulcer properties
Zusammenfassung der Kapitel (Chapter Summaries)
- ABSTRACT: This section provides a concise summary of the study's objectives, methods, results, and conclusions. It highlights the synthesis and characterization of the potassium dicitro bismuthate (III) complex and its potential antiulcer activity in rats.
- INTRODUCTION: This section introduces the importance of citric acid and its role in forming complexes with metal ions. It discusses the prevalence of peptic ulcers and the mechanisms involved in their development. The study's focus on potassium dicitro bismuthate (III) as a potential antiulcer agent is outlined, emphasizing its topical action in the gastrointestinal tract and its use in treating gastrointestinal disorders.
- MATERIALS AND METHODS: This section details the materials and procedures used in the study. It describes the preparation of the bismuth complex, its characterization methods (FTIR, conductivity, elemental analysis), and the experimental protocol for evaluating the complex's antiulcer activity in rats. This includes the induction of gastric ulcers using HCl-ethanol, the administration of the complex and Sucralfate, and the analysis of ulcer severity.
- RESULTS AND DISCUSSION: This section presents the results of the study and interprets their significance. It analyzes the FTIR spectra of citric acid and the potassium dicitro bismuthate (III) complex, providing structural insights based on the spectral data. The antiulcer activity of the complex is discussed, comparing its effectiveness to Sucralfate and highlighting its potential as a therapeutic agent.
Schlüsselwörter (Keywords)
The study focuses on citric acid, bismuth complex, antiulcer activity, and Sucralfate as key terms. It explores the potential of potassium dicitro bismuthate (III) as a therapeutic agent for gastric ulcers, particularly in comparison with the standard drug Sucralfate.
- Quote paper
- Amer Taqa (Author), 2011, Preparation of PotassiumDicitro Bismuthate Complex as Antigastric Ulcer, Munich, GRIN Verlag, https://www.hausarbeiten.de/document/209691
