A cross-sectional observational study was carried out on 152 patients with nodular thyroid lesions between January 2000 and December 2006, attended at the Endocrinology - Head and Neck Surgery clinic of the "Guillermo Domínguez López" General Teaching Hospital in Puerto Padre, who underwent fine needle aspiration biopsy (FNAB) where 22 cases were operated. 12 positives by cytology, 6 suspected and 4 by clinical and imaging data of malignancy, with the aim of specifying the clinical indications of this procedure, determining the age groups and sexes most affected by thyroid nodules, as well as the most frequent cytohistological variants in this environment and finally evaluating the degree of cytopathological and histopathological correlation of the operated cases. The studies conducted showed that the clinical indication was higher in the single thyroid nodule, with female sex and ages between 31 and 40 years prevailing. On the other hand, colloid goiter was the most frequent variety among benign lesions, while papillary carcinoma was the most representative among malignant lesions. The indication for FNA predominated in the single thyroid nodule, female sex and in the fourth decade of life, the most frequent benign nodular lesions of the thyroid was colloid goiter, while papillary carcinoma in malignant thyroid was also demonstrated a sensitivity of 100%, a specificity of 66.6% and an efficacy of 90.90%. with positive and negative predictive values of between 88.8 and 100%, respectively.
Table of Contents
- Summary
- Introduction
- Objectives
- Material and Method
Objectives and Key Themes
The main objective of this study was to improve the diagnosis of thyroid diseases, particularly those presenting as nodules, using fine needle aspiration biopsy (FNAB). The study aimed to specify clinical indications for FNAB, identify the most affected age and sex groups, determine the most frequent cytohistological variants, and evaluate the correlation between cytopathological and histopathological findings in operated cases.
- Clinical indications for FNAB in thyroid nodules
- Demographic distribution of thyroid nodules (age and sex)
- Frequency of cytohistological variants in thyroid nodules
- Correlation between cytopathological and histopathological findings
- Effectiveness and accuracy of FNAB in thyroid nodule diagnosis
Chapter Summaries
Summary: This cross-sectional observational study analyzed 152 patients with thyroid nodules from 2000-2006 who underwent FNAB. 22 patients underwent surgery. The study aimed to define clinical indications for FNAB, identify affected demographics, determine frequent cytohistological variants, and assess cytopathological-histopathological correlation. Results showed higher FNAB indication in single nodules, predominantly in women aged 31-40. Colloid goiter was the most frequent benign lesion, while papillary carcinoma was the most common malignant lesion. The study demonstrated a 100% sensitivity, 66.6% specificity, and 90.9% efficacy for FNAB.
Introduction: This chapter introduces fine needle aspiration biopsy (FNAB) as a widely used diagnostic procedure for thyroid pathology since its introduction in 1952. It discusses the accuracy and reliability of FNAB, citing various studies that support its diagnostic efficacy compared to other methods. The chapter highlights the diagnostic challenge posed by thyroid nodules, their prevalence in the population, and the importance of distinguishing between benign and malignant lesions. The high incidence of thyroid disease, particularly in women, and the potential complications of surgical intervention are emphasized, underscoring the need for accurate pre-operative diagnosis.
Objectives: This section outlines the study's general and specific objectives. The general objective focuses on enhancing the knowledge and diagnosis of thyroid diseases, especially nodular forms, through FNAB. Specific objectives include defining clinical indications for FNAB, determining the most frequent age and sex groups affected, identifying the most common cytohistological variants, and evaluating the correlation between cytopathological and histopathological findings in surgical cases. These objectives guide the study's methodology and data analysis.
Material and Method: This chapter describes the study design as a cross-sectional observational study using FNAB on patients with thyroid nodules seen between January 2000 and December 2004 at the Endocrinology and Head and Neck Surgery clinic of the "Guillermo Domínguez López" General Teaching Hospital in Puerto Padre. The methodology details the patient selection and data collection process, providing the foundation for the study's results and conclusions. The timeframe and location are clearly specified.
Keywords
Aspiration biopsy, Diagnosis, Cytohistopathology, Thyroid, Thyroid Nodules, Papillary Carcinoma, Colloid Goiter, FNAB
Frequently asked questions
What is the main topic of this language preview?
This language preview provides an overview of a study focused on improving the diagnosis of thyroid diseases, particularly thyroid nodules, using fine needle aspiration biopsy (FNAB).
What are the key objectives of the study?
The study aims to: define clinical indications for FNAB in thyroid nodules; identify the demographic distribution (age and sex) of patients with thyroid nodules; determine the frequency of cytohistological variants in thyroid nodules; evaluate the correlation between cytopathological and histopathological findings in operated cases; and assess the effectiveness and accuracy of FNAB in thyroid nodule diagnosis.
What type of study was conducted?
The study was a cross-sectional observational study.
How many patients were involved in the study?
The study analyzed 152 patients with thyroid nodules who underwent FNAB between 2000 and 2006. 22 of these patients underwent surgery.
What were the main findings of the study?
The study found that FNAB was most often indicated in cases of single nodules, predominantly in women aged 31-40. Colloid goiter was the most frequent benign lesion, and papillary carcinoma was the most common malignant lesion. FNAB demonstrated a 100% sensitivity, 66.6% specificity, and 90.9% efficacy.
What is the role of FNAB in diagnosing thyroid nodules?
FNAB is presented as a widely used diagnostic procedure for thyroid pathology, known for its accuracy and reliability in distinguishing between benign and malignant thyroid nodules.
Where was the study conducted?
The study was conducted at the Endocrinology and Head and Neck Surgery clinic of the "Guillermo Domínguez López" General Teaching Hospital in Puerto Padre.
What are some of the keywords associated with this study?
Keywords include: Aspiration biopsy, Diagnosis, Cytohistopathology, Thyroid, Thyroid Nodules, Papillary Carcinoma, Colloid Goiter, and FNAB.
What time frame did this study cover?
Data was collected from January 2000 to December 2004 for patient selection and methodology but the full study covers data from 2000-2006.
- Quote paper
- Dr. Manuel Medina Suarez (Author), Dr. Alfredo Vallés Gamboa (Author), Dr. Lisander Acosta Vergés (Author), Dr. Grisel Cuesta (Author), Manuel Javier Medina Rodriguez (Author), 2007, Cytopathology in thyroid nodule, Munich, GRIN Verlag, https://www.hausarbeiten.de/document/1604320
