The aim of this research is to compare the physicochemical and release properties of amoxicillin trihydrate tablets 500mg using different binder (Peptin powder B.P, Microcrystalline cellulose and Corn starch mucilage at different concentration of 5%, 7.5%, 10% and 12.5%) to evaluate the hardness, thickness, tensile strength, weight uniformity, friability, disintegration time, dissolution rate/absorbance, moisture content and FTIR . It was revealed from the result of the study that the angle of repose varied from 30.2 ±2.96 to 27.2 ±1.2. This shows that the granules had good flow property as they were below 30o which indicates the granules is free flowing. The bulk density was found to be in the range of 0.56 ±0.05 to 0.54 ±0.056. As the granule size increases, bulk density decreases. The tapped density range from 0.65 ±0.06 to 0.65 ±0.06 while compressibility index was between 17.41 ±12.6 to 8.92 ±3.61. This was less than 10% indicated in the British Pharmacopeia from excellent flow character. This indicates that the granules had excellent flow character. The Housners ratio ranged from 0.825 ±0.09 to 0.92 ±0.035 for the different batches. The batches within 1.00 – 1.11 range had excellent flow character while the batches within the range of 0.83-0.825 had good flow character but not as the other batches. The physiochemical evaluations of the amoxicillin granules showed good flow character. All the sample passes friability test with range of 1.0 above except for two sample (corn starch mucilage 5%w/w and 5% microcrystalline cellulose that fall below 1.0%). Uniformity in tablet diameter depends on diameter of the punch use for the compression process the standard deviation permitted is ±5% of the mean diameter (British Pharmacopoeia). To this regard all the tablet passed the test by corresponding to stated standard with the range of 0.57g-0.58g. The standard binder efficiency is <30% to achieve good granule friability, however, the results for all sample shows below 30% this indicate good binding potential in pharmaceutical formulations. For hardness test, they was an increase in values as the concentration increases with the range (CSM 3.96 - 5.5, PTN 2.67 to 4.0 and MCC 3.9 to 4.9) kg respectively.
Inhaltsverzeichnis (Table of Contents)
- Chapter One: Introduction
- Background to the Study
- Statement of Problem
- Aims of the Study
- Objective of the Study
- Significance of Study
- Scope of Study
- Chapter Two: Literature Review
- Literature Review
- Amoxicillin Tablets
- Microcrystalline cellulose
- Corn Starch Mucilage
- Pectin Powder B.P
- Tablet
- Types of Tablets
- Advantages of the Tablets
- Tablet Processing
- Excipients
- History of Excipients
- Classification of Excipients
- Excipient Uses and Benefits
- Possible Side Effects of Excipients
- Excipients Toxicities (cases)
- Lactose Anhydrous as Bulk Agent
- Magnetism Stearate B.P
- Corn Starch as Disintegrant
- Talc Powder
- Amoxicillin
- Market Value of the Drug
- Drug Resistance
- Mode of Action
- Physical Properties
- Analytical Methodologies
- Pharmacokinetic Aspects
- Adverse Effects
- Drug Interactions
- Clinical Indications
- Chapter Three: Materials and Method
- Materials and Equipment Used
- Methods
- Pre-formulation Studies
- Organoleptic Evaluation
- Formulation Studies
- Preparation Granules
- Flow Properties of Granules
- Evaluation of Tablets
- Physiochemical Properties
- Chapter Four: Results and Discussion
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
This study aims to comparatively analyze the physicochemical and release properties of amoxicillin trihydrate tablets formulated with different types of binders. The research investigates the impact of binder selection on tablet characteristics and drug release.
- Comparative analysis of different binders in amoxicillin tablet formulation.
- Evaluation of physicochemical properties of the formulated tablets.
- Assessment of drug release profiles from tablets with varying binders.
- Determination of the optimal binder for amoxicillin tablet formulation.
- Understanding the impact of binder properties on tablet performance.
Zusammenfassung der Kapitel (Chapter Summaries)
Chapter One: Introduction: This chapter sets the stage for the research by providing background information on amoxicillin tablets and the importance of binder selection in tablet formulation. It clearly states the problem addressed by the study, its objectives, significance, and scope. The chapter highlights the need for improved amoxicillin tablet formulations and emphasizes the role of different binders in achieving optimal physicochemical and release properties.
Chapter Two: Literature Review: This chapter provides a comprehensive overview of existing literature related to amoxicillin tablets, different types of binders (microcrystalline cellulose, corn starch mucilage, pectin), and other tablet excipients. It delves into the properties, pharmaceutical uses, and potential side effects of these components. The review also covers the analytical methodologies, pharmacokinetic aspects, and clinical applications of amoxicillin, establishing a strong foundation for the experimental work described in subsequent chapters. The chapter thoroughly explores the existing knowledge on amoxicillin and its formulation, providing a framework for understanding the research objectives and expected outcomes.
Chapter Three: Materials and Method: This chapter details the materials, equipment, and procedures used in the study. It outlines the pre-formulation studies conducted to characterize the chosen binders and amoxicillin. Furthermore, it provides a step-by-step description of the tablet formulation process, including granule preparation and evaluation, and the methods employed to assess the physicochemical properties of the final tablets. The meticulous description of the methodology ensures the reproducibility and validity of the research findings. The chapter's focus is on the experimental design and execution to ensure clear and accurate documentation.
Schlüsselwörter (Keywords)
Amoxicillin, tablet formulation, binders, microcrystalline cellulose, corn starch mucilage, pectin, physicochemical properties, drug release, pre-formulation studies, tablet characteristics, dissolution profile.
Frequently Asked Questions: Comprehensive Language Preview of Amoxicillin Tablet Formulation
What is the overall topic of this document?
This document provides a comprehensive preview of a research study focusing on the formulation of amoxicillin trihydrate tablets. It details the study's objectives, methodology, and expected outcomes, covering aspects from literature review to results and discussion.
What are the main chapters included in the study?
The study is structured into four main chapters: Chapter One (Introduction), Chapter Two (Literature Review), Chapter Three (Materials and Methods), and Chapter Four (Results and Discussion). The introduction sets the context, the literature review provides background information, the materials and methods section outlines the experimental procedures, and the final chapter presents and discusses the findings.
What are the key objectives of the research study?
The primary objective is to comparatively analyze the physicochemical and release properties of amoxicillin trihydrate tablets formulated with different types of binders (microcrystalline cellulose, corn starch mucilage, pectin). The study aims to determine the optimal binder for amoxicillin tablet formulation based on tablet characteristics and drug release profiles.
What binders are compared in this study?
The study compares the performance of three different binders: microcrystalline cellulose, corn starch mucilage, and pectin powder B.P. in amoxicillin tablet formulations. The impact of these binders on the physicochemical properties and drug release profiles of the tablets will be evaluated.
What are the key physicochemical properties evaluated in the tablets?
The research will evaluate various physicochemical properties of the formulated tablets. While specific tests aren't explicitly listed in the preview, the mention of pre-formulation studies and evaluation of tablets suggests parameters such as tablet hardness, disintegration time, dissolution rate, and potentially others will be assessed.
What is the significance of this research?
The research aims to improve amoxicillin tablet formulations by identifying the optimal binder for achieving superior physicochemical properties and drug release characteristics. This is important for enhancing the effectiveness and bioavailability of the drug.
What methods are used in the study?
The methodology includes pre-formulation studies (organoleptic evaluation), formulation studies (granule preparation and evaluation), and tablet evaluation to assess the physicochemical properties. Specific methods used in each stage are detailed in Chapter Three.
What aspects of amoxicillin are covered in the literature review?
The literature review comprehensively covers various aspects of amoxicillin, including its properties, market value, drug resistance, mode of action, analytical methodologies, pharmacokinetic aspects, adverse effects, drug interactions, and clinical indications. It also explores the properties and uses of excipients, such as microcrystalline cellulose, corn starch mucilage, and pectin.
What are the key words associated with this research?
Key words associated with the research include Amoxicillin, tablet formulation, binders, microcrystalline cellulose, corn starch mucilage, pectin, physicochemical properties, drug release, pre-formulation studies, tablet characteristics, and dissolution profile.
Where can I find more detailed information about the study?
The complete study, including the detailed results and discussion, is not included in this preview. Contact the publishing company for access to the full research paper.
- Quote paper
- Peter Ugwu Akor (Author), 2022, Comparative Analysis of the Physicochemical and Release Properties of Amoxicillin Trihydrate Tablets Formulated with Different Types of Binders, Munich, GRIN Verlag, https://www.hausarbeiten.de/document/1366972
